Enzyme steps in aflatoxin biosynthesis
نویسندگان
چکیده
منابع مشابه
Aspergillus parasiticus cyclase catalyzes two dehydration steps in aflatoxin biosynthesis.
In the aflatoxin biosynthetic pathway, 5'-oxoaverantin (OAVN) cyclase, the cytosolic enzyme, catalyzes the reaction from OAVN to (2'S,5'S)-averufin (AVR) (E. Sakuno, K. Yabe, and H. Nakajima, Appl. Environ. Microbiol. 69:6418-6426, 2003). Interestingly, the N-terminal 25-amino-acid sequence of OAVN cyclase completely matched an internal sequence of the versiconal (VHOH) cyclase that was deduced...
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Aflatoxins are toxic and extremely carcinogenic natural secondary metabolites produced primarily by the fungi Aspergillus flavus and Aspergillus parasiticus. The biosynthesis of aflatoxins is a complex process involving multi-enzymatic reactions. Genetic studies of the molecular mechanism of aflatoxin B1 biosynthesis have identified an aflatoxin pathway gene cluster of 70 kilobase pairs in leng...
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The enzymology of secondary metabolism has not received the same attention as that for primary (general) metabolism. There are traditional and other reasons for this bias, some of which will become apparent in this review. With the advent of recombinant deoxyribonucleic acid technology (genetic engineering), it seems inevitable that this state of affairs should change. Many secondary metabolite...
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Occurrence of aflatoxins in crops has vast impacts on human health. Therefore, the study of aflatoxin biosynthesis has become important. Previous studies have shown that the aflatoxin biosynthesis gene cluster and several genes, enzymes, and regulatory elements are involved in aflatoxin biosynthesis; however, the intricate metabolic regulatory networks of aflatoxin synthesis remain unclear. Rap...
متن کاملTwo distinct O-methyltransferases in aflatoxin biosynthesis.
The substances belonging to the sterigmatocystin group bear a close structural relationship to aflatoxins. When demethylsterigmatocystin (DMST) was fed to Aspergillus parasiticus NIAH-26, which endogenously produces neither aflatoxins nor precursors in YES medium, aflatoxins B1 and G1 were produced. When dihydrodemethylsterigmatocystin (DHDMST) was fed to this mutant, aflatoxins B2 and G2 were ...
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ژورنال
عنوان ژورنال: Mycotoxins
سال: 2003
ISSN: 0285-1466,1881-0128
DOI: 10.2520/myco1975.2003.suppl3_133